ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration
Adolescent idiopathic scoliosis (AIS), a complex early-onset three-dimensional spinal deformity, remains etiologically ambiguous despite extensive ongoing investigations.Currently, braces and surgeries are primary treatments of AIS, which come with inherent risks and costs.Therefore, there is an urgent need for biotherapeutic targets for AIS.Using